General Secretary

Dr. Prem Man Singh Chauhan,FRSC
Medicinal Chemistry Division, Central Drug Research Institute
Lucknow -226001, India.
email: premsc58@hotmail.com
           prem_chauhan_2000@yahoo.com
 
Post Doctoral Experience                                           Jan 1987 - Oct 1988
Senior Research Associate (Engineering and Physical Sciences Research Council (EPSRC), U.K.) Robert Robinson Laboratory, University of Liverpool, UK ( with Dr.R.C.Storr).  

DAAD Visiting Scientist                                               April 2000 - July 2000
Senior DAAD Visiting Scientist, Instituted of Organic Chemistry, Aachen, Germany (with Prof.D.Enders and Prof Stefan Brease).  

Post Doctoral Senior Research Associate                   2002 - 2003
School of Chemical Sciences, University East Anglia, Norwich, UK ( with Prof.David Horwell).

Research Experience
Synthetic Organic Chemistry (23 years), Medicinal Chemistry (23 years), Combinatorial Chemistry (6years).

Current area of Interest
Synthesis of novel heterocycles as antiinfective and anticancer agents.
Total Paper : 75
Patents : 7

Selected publications:

Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β -carbolines as a new class of antimalarial agents,Leena Gupta,Kumkum Srivastava, Shubhra Singh,       S. K. Puri and Prem M. S. Chauhan*, Bioorganic and Medicinal Chemistry Letters, 18, 2008, 3306-3309.


1. One-pot chemoselective S-alkylation and acetylation of thiohydantoins using alkyl orthoformate-ZnCl2-Ac2O reagent system,Ravi Kumar and Prem M. S. Chauhan Ravi Kumar and Prem M. S. Chauhan*, Tetrahedron Letters 49 ,2008, 5475–5479.
   
   
2. Synthesis of Marine alkaloid: 8, 9-Dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents,Leena Gupta,Archna Talwa, Nishi, Shraddha Palne,Suman Gupta and
   Prem M. S. Chauhan*, Bioorganic and Medicinal Chemistry Letters,2007,17, 4075–4079.
   
   
3. Bis and Tris Indole Alkaloids from Marine Organisms:New Leads For Drug Discovery, Leena Gupta,  Archna Talwar and Prem M.S.Chauhan*, Current Medicinal Chemistry, 2007, 14,  16, 1789-1803.
   
   
4. Syntheses of new substituted triazino tetrahydro-isoquinlines and β-carbolines as novel antileishmanial agents, Arun Kumar, Sanjay Babu Katiyar, Suman Gupta and Prem M. S. Chauhan, European Journal of Medicinal Chemistry, 2006, 41 ,106–113.
   
   
5. A Multicomponent Reaction: Efficiently furnishing Phenylmethylene-2-thiohydantoin with some unusual consequences.Sharad Porwal, Rishi Kumar,b Prakas R. Maulik,and Prem M. S. Chauhan, Tetrahedron Letters ,2006 , 47,5863–5866.
   
   
6. Facile synthesis of pyrazolo[3,4-d]pyrimidines and pyrimido [4,5-d]pyrimidin-4-one derivatives,Sanjay Babu Katiyar, Arun Kumar and Prem M. S. Chauhan, Synthetic communications, 36(20), 2006 , 2963-73.
   
   
7. Synthesis of 2,4,6-trisubstituted pyrimidine and triazineheterocycles as antileishmanial agents ,Naresh Sunduru, Anu Agarwal,Sanjay Babu Katiyar,Nishi, Neena Goyal,,Suman Gupta and Prem M.S. Chauhan, Bioorganic and Medicinal Chemistry, 14, 2006,7706-7715.
   
   
8. Microwave assisted one pot synthesis of new bis-imidazolyl indoles, Anu Agarwal ,Sharad porwal and Prem M. S. Chauhan,, Letters in Organic Chemistry, 3,2006,712-714.
   
   
9. Syntheses of 2, 4, 6-trisustituted pyrimidine derivatives as Antifilarial topoisomerase II inhibitors Sanjay Babu Katiyar, Iti Bansal, J. K. Saxena and P. M. S. Chauhan, Bioorganic and Medicinal Chemistry Letters , 2005, 15/1, 47-50.
   
   
10. Solid supported synthesis of structurally diverse dihydropyrido[2,3-d] pyrimidines using microwave irradiation, Anu Agarwal and P.M.S. Chauhan, Tetrahedron Lett. 2005, 46 (8), 1345-1348.
    
    
11. Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents, Anu Agarwal, Kumkum Srivastava,S.K. Puri and Prem M.S. Chauhan Bioorganic and Medicinal Chemistry Letters , 2005, 15, 531-533.
    
    
12. Antimalarial activity of 2,4,6-trisubstituted pyrimidines. Anu Agarwal, Kumkum Srivastava, S.K. Puri and Prem M.S. Chauhan, Bioorganic and Medicinal Chemistry Letters, 2005, 15, 1881-1883.
    
    
13. Syntheses of novel heterocycles as anticancer agents,Prem M. S. Chauhan,Cristina J. A. Martins and David C. Horwell ,Bioorganic and Medicinal Chemistry, 13 (2005) 3513–3518.
    
    
14. Synthesis of substituted indole derivatives as a new class of antimalarial agents Anu Agarwal, Kumkum Srivastava, S.K. Puri and Prem M.S. Chauhan Bioorganic and Medicinal Chemistry Letters, 2005, 15, 3133-3136.
    
    
15. Antimalarial activity and synthesis of new trisubstituted pyrimidines. Anu Agarwal, Kumkum Srivastava, S.K. Puri and Prem M.S. Chauhan Bioorganic and Medicinal Chemistry Letters 2005, 15, 3130-3132.
    
    
16. Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents ,Anu Agarwal, Kumkum Srivastava, S.K. Puri and Prem M.S. Chauhan, Bioorganic and Medicinal Chemistry, 2005, 13, 4645-4650.
    
    
17. Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents Anu Agarwal, Kumkum Srivastava, S.K. Puri and Prem M.S. Chauhan Bioorganic and Medicinal Chemistry, 2005 13 (2005) 6226–6232.
    
    
18. Dihydropyrido[2,3-d]pyrimidines as a new class antileishmanial agents Anu Agarwal, Ramesh, Neena Goyal, Prem M.S. Chauhan, Suman Gupta, Bioorganic and Medicinal Chemistry Letters 13 (2005) 6678–6684.
    
    
19. Solid support synthesis of 6-aryl-2-substituted pyrimdin-4-yl phenols as anti-infective agents Anu Agarwal, Kumkum Srivastava, S.K. Puri, S. Sinha and Prem M.S. Chauhan Bioorganic and Medicinal Chemistry Letters 15 (2005) 4923–4926.
    
    
20. A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents Anu Agarwal, Kumkum Srivastava, S.K. Puri, S. Sinha and Prem M.S. Chauhan, Bioorganic and Medicinal Chemistry Letters 15 (2005) 5218-5221.
    
    
21. Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents, Sanjay Babu Katiyar, Kumkum Srivastava, S.K. Puri, P.M.S Chauhan,Bioorganic and Medicinal Chemistry Letters 2005, 15 (2005) 4957–4960.
    
    
22. Syntheses of novel Antimycobacterial Combinatorial libraries of structurally diverse substituted pyrimidines by three component solid phase reactions ,Arun Kumar, Sudhir Sinha and PMS Chauhan* , Bioorganic and Medicinal Chemistry Letters ,2002, 12, 667-669.
    
    
23. Quinolones : Novel Probes in Antifilarial Chemotherapy. S. Srivastava, P. M. S. Chauhan*, A. P. Bhaduri , N Fatima, R. K. Chatterjee, J .Medicinal Chemistry, 2000 43,2275-79.
    
    
24. Secondary amines as new pharmacophores as for macrofilaricidal drug. S. Srivastava, P. M. S. Chauhan*, A. P. Bhaduri , N Fatima, R. K. Chatterjee, Bioorganic and Medicinal Chemistry Letters, 2000, 10, 313-314.
    
    
25. Potent 1,3- disubstitued 9H-pyrido [3,4-b] indoles as new lead compounds in antifiarial chemotherapy , Sanjay K. Shrivastava, A. Agarwal , P.M.S. Chauhan*, S.K. Agarwal , A.P. Bhaduri , S.N. Singh , Nigar Fatima , R.K. Chatterjee , J. Medicinal Chemistry (1999) , 42, 1667-1672.
    
    
26. Synthesis and antifilarial profile of 5 , 8-diamino isoquinolines Sanjy K. Shrivastava , P.M.S. Chauhan*, A.P. Bhaduri , S.K. Agarwal, S.N. Singh , Nigar Fatima , R.K. Chatterjee , V.M.L. Shrivastava , Bioorganic and Medicinal Chemistry Letters ,(1996) , 6 , 2623-2628.
    
    
Novel site specific one step bromination of substituted benzenes, Sanjy K. Shrivastava , P.M.S. Chauhan*, A.P. Bhaduri , J. Chem. Soc. Chem. Comm. (1996) , 2679-2680.

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